| Datum | Competitie | Thuis | Tijd | Uit | |
|---|---|---|---|---|---|
| 26/09 /21 | Supercup Apeldoorn | Draisma Dynamo | Amysoft Lycurgus | ||
| 02/10 /21 | Eredivisie | RECO ZVH | 19:30 | Amysoft Lycurgus | |
| 03/10 /21 | Eredivisie | Amysoft Lycurgus | 15:00 | Bielderman Koetsier SSS | |
| 16/10 /21 | Eredivisie | Amysoft Lycurgus | 20:00 | ComputerPlan VCN | |
| 24/10 /21 | Eredivisie | Amysoft Lycurgus | 15:00 | Sliedrecht Sport | |
| 30/10 /21 | Eredivisie | Draisma Dynamo | 20:00 | Amysoft Lycurgus | |
| 06/11 /21 | Eredivisie | Amysoft Lycurgus | 20:00 | VC Limac | |
| 20/11 /21 | Eredivisie | Active Living Orion | 20:30 | Amysoft Lycurgus | |
| 24/11 /21 | Eredivisie | Amysoft Lycurgus | 20:00 | VoCASA | |
| 27/11 /21 | Eredivisie | Taurus | 20:00 | Amysoft Lycurgus | |
| 04/12 /21 | Beker 1/8 finale | ||||
| 12/12 /21 | Eredivisie | Amysoft Lycurgus | 17:00 | TT Papendal | |
| 18/12 /21 | Eredivisie | Simplex SSS | 19:30 | Amysoft Lycurgus | |
| 08/01 /22 | Eredivisie | Amysoft Lycurgus | 20:00 | Draisma Dynamo | |
| 15/01 /22 | Eredivisie | Sliedrecht Sport | 20:00 | Amysoft Lycurgus | |
| 30/01 /22 | Eredivisie | VC Limac | 15:00 | Amysoft Lycurgus | |
| 12/02 /22 | Eredivisie | Amysoft Lycurgus | 16:00 | Active Living Orion | |
| 13/02 /22 | Eredivisie | ComputerPlan VCN | 18:30 | Amysoft Lycurgus | |
| 16/02 /22 | Eredivisie | VoCASA | 20:00 | Amysoft Lycurgus | |
| 19/02 /22 | Eredivisie | Amysoft Lycurgus | 20:00 | Taurus | |
| 26/02 /22 | Eredivisie | TT Papendal | 17:00 | Amysoft Lycurgus | |
| 05/03 /22 | Eredivisie | Amysoft Lycurgus | 20:00 | RECO ZVH |
